Sequencing Informatics

Next-Generation DNA Sequencing Informatics

This site supplements Stuart Brown's book, Next-Generation DNA Sequencing Informatics, published by Cold Spring Harbor Laboratory Press. The site contains an NGS glossary, links to various NGS online resources, the book chapters for sale in PDF format, and tutorials. We will add more tutorials and resources in the future.

Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making complete genome sequencing an affordable and frequently used tool for a wide variety of research applications. Bioinformatics methods to support DNA sequencing have become a critical bottleneck for many researchers and organizations wishing to make use of NGS technology. Next-Generation DNA Sequencing Informatics provides a thorough introduction to the necessary informatics methods and tools for operating NGS instruments and analyzing NGS data, extensive reference to best-practice bioinformatic methods for the most commonly used NGS technologies and applications, and reference to, and guidance on, the setup and use of essential software for NGS data analysis.